Research Information System
Kuwait Medical Journal, vol.54, no.2, pp.163-171, 2022 (SCI-Expanded, Scopus)
© 2022, Kuwait Medical Association. All rights reserved.Objective: Previous studies have shown that the neutrophil to lymphocyte ratio (NLR), an indicator of systemic inflammation, is associated with mortality in patients with ST-segment elevation myocardial infarction (STEMI). The association between the timing of NLR measurements and short-and long-term outcomes is not clear. Design: Prospective study Setting: Tertiary university hospital Subjects: One hundred and ten consecutive patients with STEMI who were treated with primary percutaneous coronary intervention (PCI) were enrolled prospectively in the study in a tertiary hospital over 9 months. Interventions: NLRs at admission and 4, 24 and 48 hours after admission were compared to determine outcomes in patients with STEMI who were treated with primary PCI. Main Outcome measure: In this study with 5-year follow-up, we aimed to determine the appropriate timing of NLR to predict 30-day and 5-year mortality in patients with STEMI undergoing primary PCI. Results: Remarkably, in our study, NLR at 48 hours after admission was more accurate for predicting major adverse cardiac events (MACE) within 30 days, as well as 5-year mortality. Nevertheless, we found that NLR, when time was not taken into consideration, was also associated with mortality at 30-day and 5-year follow-up and MACE at 30-day follow-up. Conclusion: Our findings indicate that NLR at 48 hours after admission or before discharge is more accurate for predicting clinical outcomes in patients with STEMI.