© 2021 Elsevier Inc.Background: The aim of the study was to evaluate the effect of Tai Chi on functional mobility, balance and falls in Parkinson's disease. Materials and methods: A comprehensive literature search was conducted to identify the systematic reviews and meta-analyses up to the end of October 2021. 601 studies were identified, and 16 of them were included in our study. Results: According to our meta-analysis; there was a significant effect of Tai Chi on balance (SMD, −0.777 95% CI −0.921 to -0.633; p = 0.000), functional mobility (SMD, −0.719 95% CI −0.944 to -0.494; p = 0.000), and falls (SMD, −0.456 95% CI −0.668 to -0.245; p = 0.000) in PD. Conclusion: Our systematic review and meta-analysis found significant effects of Tai Chi on functional mobility, balance and falls in patients with PD.