The Effects of CCl4 on Na+/K+-ATPase and Trace Elements in Rats

AKYÜZ F., Aydin O., Demir T. A., Kanbak G.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.132, pp.207-214, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 132
  • Publication Date: 2009
  • Doi Number: 10.1007/s12011-009-8395-9
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.207-214
  • Eskisehir Osmangazi University Affiliated: Yes


CCl4 is an industrial agent with known toxic effects on the environment. There are so many studies about hepatotoxic effects of CCl4. We herein studied the effects of CCl4 on Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities on erythrocyte membranes and trace element levels of serum erythrocyte and liver tissue of rats. Study was performed on control group (group C, n = 8) and a study group (group S, n = 8) in which CCl4 was given. Na+/K+-ATPase and Ca2+/Mg2+-ATPase were significantly reduced in CCl4-treated group (p < 0.01, p < 0.001). Trace element levels also showed statistically significant differences in CCl4-treated group. Membrane Na+/K+-ATPase and Ca2+/Mg2+-ATPase activities were diminished due to CCl4-induced injury on erythrocyte membranes. CCl4 also changed the trace element levels of serum erythrocyte membrane and liver by altering the mineral substance concentrations.