The superiority of Dexpanthenol or Vaseline as excipient in nasal formulations.

Necati Develioglu O., Dilber M., Bayar Muluk N., Vejselova Sezer C., Mehtap Kutlu H., Topsakal V., ...More

European review for medical and pharmacological sciences, vol.26, no.2 Suppl, pp.124-133, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2 Suppl
  • Publication Date: 2022
  • Doi Number: 10.26355/eurrev_202212_30496
  • Journal Name: European review for medical and pharmacological sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.124-133
  • Keywords: Dexpanthenol, Vaseline, Nasal formulation, Intranasal application, PLUS DEXPANTHENOL, SJOGRENS-SYNDROME, RHINITIS, INFLAMMATION, PERFORMANCE, ISCHEMIA, EFFICACY, SURGERY, PACKING, INJURY
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

OBJECTIVE: Dexpanthenol is an ingredient in multiple topical pharmaceutical preparations thanks to its high penetration and localized concentration. It is included in many ointments or lotions for dermatological use, assisting in healing and reducing pruritus. Vaseline is a synthetic product obtained by distilling crude oil. It is commercially available in several grades. The study presented here examined how topically applied agents (dexpanthenol or vaseline) affect nasal epithelial cells in culture. In particular, the study aimed to identify any alterations to epithelial cells which might indicate toxicity.