Effects of ivabradine and beta-blocker therapy on dobutamine-induced ventricular arrhythmias

Mert K. U., Mert G. Ö., Morrad B., Tahmazov S., MUTLU F., ÇAVUŞOĞLU Y.

KARDIOLOGIA POLSKA, vol.75, no.8, pp.786-793, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.5603/kp.a2017.0094
  • Journal Name: KARDIOLOGIA POLSKA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.786-793
  • Keywords: ivabradine, heart failure, arrhythmias, CONGESTIVE-HEART-FAILURE, NERVOUS-SYSTEM, RATE REDUCTION, HCN CHANNELS, I-F, MORTALITY, ISCHEMIA, DEATH, TRIAL
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Indirect evidences suggest that the If blocker ivabradine may exert an antiarrhythmic effect in ventricular myocardium in heart failure (HF) patients by inhibiting spontaneous depolarisations, but the clinical relevance of this mechanism is not known. Dobutamine (DOB) has been known to increase heart rate and the incidence of cardiac arrhythmias.