Potentiometric sensor fabrication having 2D sarcosine memories and analytical features

BİRLİK ÖZKÜTÜK E., EMİR DİLTEMİZ S., Avci S., Ugurag D., Aykanat R. B., Ersoz A., ...More

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol.69, pp.231-235, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2016
  • Doi Number: 10.1016/j.msec.2016.06.057
  • Journal Name: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.231-235
  • Keywords: Prostate cancer, Potentiometric sensor, Sarcosine, MIP, MOLECULARLY IMPRINTED POLYMER, ION-SELECTIVE ELECTRODES, SOLID-PHASE EXTRACTION, CARBON-PASTE ELECTRODE, ELECTROCHEMICAL SENSOR, LIQUID-CHROMATOGRAPHY, MASS-SPECTROMETRY, TECHNICAL REPORT, AMINO-ACIDS, FOLIC-ACID
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

In this study, a simple, rapid and sensitive method based on novel molecular imprinted polymeric sensor has been developed and validated for the determination of prostate cancer metabolite biomarker. The molecularly imprinted polymer (MIP) has been synthesized by emulsion polymerization, using sarcosine as template molecule, methacryloylamido histidine (MAH) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linking agent. The performance of the developed sarcosine sensor has been evaluated, and the results have indicated that a sensitive potentiometric sensor has been fabricated. The sarcosine sensor has showed high-selectivity, shorter response time (<2 min), wider linear range (10(-2)-10(-6) mM), lower detection limit (1.35 x 10(-7) mM), and satisfactory long-term stability (>5.5 months). (C) 2016 Elsevier B.V. All rights reserved.