Hypercalcemia and Acute Kidney Injury Due to Oral Vitamin D Replacement

Bozaci I., Avci T., Nalbant S., Vasi I., SOYDAN M.

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, vol.27, no.2, pp.221-224, 2018 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5262/tndt.2018.2827
  • Page Numbers: pp.221-224


Vitamin D (calciferol), is a fat-soluble vitamin and it is contained in very few foods. The main source of this vitamin is skin production. Subclinical vitamin D deficiency, diagnosed by a low 25 hydroxy vitamin D level, is a very common disorder. The first step in the evaluation of a patient with hypercalcemia is to verify the condition with a repeat measurement. After that, differential diagnosis of parathormone (PTH) mediated and non PTH mediated hypercalcemia should be performed by the measurement of PTH. A 71-year-old female patient presented to the hospital with a history of nausea, loss of appetite, and confusion for 1 week. Hypercalcemia and acute kidney injury, linked to oral vitamin D replacement, were detected. Vitamin D has many important effects on various systems and paying attention to the total replacement dosage is as important as treating the deficiency itself.