Future Treatment of Alzheimer Disease


Keskin A. O. , Durmaz Çelik F. N. , Uncu G., Erzurumluoğlu Gökalp E. , Yıldırım Z., Tuncer E. N. , ...More

in: Geriatric Medicine and Gerontology, Dr. Edward T. Zawada Jr., Editor, IntechOpen, London, pp.1-27, 2019

  • Publication Type: Book Chapter / Chapter Vocational Book
  • Publication Date: 2019
  • Publisher: IntechOpen
  • City: London
  • Page Numbers: pp.1-27
  • Editors: Dr. Edward T. Zawada Jr., Editor

Abstract

Alzheimer’s disease is an age-related progressive neurodegenerative disorder. The two major neuropathologic hallmarks of Alzheimer’s disease (AD) are extracellular Amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). A number of additional pathogenic mechanisms, possibly overlapping with Aβ plaques and NFTs formation, have been described, including inflammation, oxidative damage, iron dysregulation, cholesterol metabolism. To date, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance. To block the progression of the disease they have to interfere with the pathogenic steps responsible for the clinical symptoms, including the deposition of extracellular amyloid β plaques and intracellular neurofibrillary tangle formation, inflammation and stem cell. In this review, we discuss new potential disease-modifying therapies for AD that are currently being studied in phase I–III trials.