Expression of proteins associated with cell-matrix adhesion in proliferative vitreoretinopathy designed by Dispase model

Isiksoy S., Basmak H., Dundar E., Ozer A.

EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol.17, no.1, pp.89-103, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1177/112067210701700113
  • Journal Name: EUROPEAN JOURNAL OF OPHTHALMOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-103
  • Keywords: CD44, vinculin, proliferative vitreoretinopathy, PIGMENT EPITHELIAL-CELLS, HUMAN EPIRETINAL MEMBRANES, FIBRILLARY ACIDIC PROTEIN, SMOOTH MUSCLE ACTIN, XR1 GLIAL-CELLS, MULLER CELLS, IMMUNOCYTOCHEMICAL IDENTIFICATION, CYTOKERATIN FILAMENTS, DIABETIC-RETINOPATHY, ANTIGENIC CHANGES
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

PURPOSE. During recent years, the interaction of cell surface molecule, extracellular matrix proteins, and cytoskeletal elements has been a topic for research for the purpose of understanding the mechanisms of pathologic conditions. This study aims to evaluate the expression of CD44, as a cell surface adhesion molecule; fibronectin (FN), as an extracellular and a cell surface protein; vinculin and actin/alpha-smooth muscle actin (alpha-SMA), as cytoskeletal elements; and the interactions of these proteins in the microenvironment of proliferative vitreoretinopathy (PVR).