Synthesis and anticonvulsant activity of some (2/4- substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones
Farmaco, vol.54, pp.842-845, 1999 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 54
- Publication Date: 1999
- Doi Number: 10.1016/s0014-827x(99)00110-x
- Journal Name: Farmaco
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.842-845
- Keywords: anticonvulsant activity, acetohydrazones, pentylenetetrazole, DERIVATIVES, 2(3H)-BENZOXAZOLONE, ARYL
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3- yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others.