Synthesis and anticonvulsant activity of some (2/4- substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

Cakir, B; Yildirim, ENGİN; Ercanli, T; Erol, K; Sahin, MF

doi:10.1016/s0014-827x(99)00110-x

Synthesis and anticonvulsant activity of some (2/4- substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

Cakir B., Yildirim E., Ercanli T., Erol K., Sahin M.

Farmaco, cilt.54, ss.842-845, 1999 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 54
Basım Tarihi: 1999
Doi Numarası: 10.1016/s0014-827x(99)00110-x
Dergi Adı: Farmaco
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.842-845
Anahtar Kelimeler: anticonvulsant activity, acetohydrazones, pentylenetetrazole, DERIVATIVES, 2(3H)-BENZOXAZOLONE, ARYL
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3- yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others.