DEFB4A Promoter Polymorphism Is Associated with Chronic Periodontitis: A Case-Control Study

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Kurt-Bayrakdar S., ÖZTÜRK A., KARA N.

GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.24, sa.3, ss.113-119, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1089/gtmb.2019.0218
  • Dergi Adı: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.113-119
  • Anahtar Kelimeler: periodontal disease, genetic susceptibility, multisite variant, promoter, association, GINGIVAL CREVICULAR FLUID, COPY NUMBER VARIATION, ANTIMICROBIAL PEPTIDES, HUMAN BETA-DEFENSIN-2, GENE-EXPRESSION, DEFENSINS, SUSCEPTIBILITY, HEALTH, HBD-1, SNP
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Human beta-defensin-2 is an antimicrobial weapon peptide with antibiotic properties secreted by the oral cavity to protect the host against microbial attack. The interindividual differences of defensin expression profiles due to genetic variation might be partly responsible for differences in disease susceptibility.