Epithelioid angiomyolipoma of the kidney
INTERNATIONAL JOURNAL OF UROLOGY, vol.12, no.2, pp.204-207, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 12 Issue: 2
- Publication Date: 2005
- Doi Number: 10.1111/j.1442-2042.2005.01003.x
- Journal Name: INTERNATIONAL JOURNAL OF UROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.204-207
- Keywords: epithelioid cells, immunohistochemistry, renal tumor, RENAL ANGIOMYOLIPOMA, CELL, CARCINOMA
- Open Archive Collection: AVESIS Open Access Collection
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
Epithelioid angiomyolipoma is a recently recognized variant of angiomyolipoma, which is characterized by the presence of polygonal cells with densely eosinophilic cytoplasm and varying degrees of nuclear atypia. Only a relatively small number of cases of epithelioid angiomyolipoma of the kidney have been reported in the literature. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 38-year-old woman. The tumor was composed of diffuse sheets of epithelioid cells, adipocytes and only scattered thick-walled blood vessels. The epithelioid cells had pleomorphic and hyperchromatic nuclei with densely eosinophilic cytoplasm. Hemorrhage, necrotic foci and clusters of foamy macrophages were present. HMB-45, CD117 (c-kit) and CD68 were detected in the epithelioid cells. There was no expression of cytokeratin, epithelial membrane antigen or desmin. The patient showed no evidence of recurrence or metastatic disease 9 months after nephrectomy.