Lactobacillus reuteri DSM 17938 effectively reduces the duration of acute diarrhoea in hospitalised children

DİNLEYİCİ E. Ç., Vandenplas Y.

ACTA PAEDIATRICA, vol.103, no.7, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1111/apa.12617
  • Journal Name: ACTA PAEDIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: (Acute) Gastroenteritis, Diarrhoea, Hospitalisation, Lactobacillus reuteri DSM 17938, Probiotics, RANDOMIZED CLINICAL-TRIAL, SACCHAROMYCES-BOULARDII, ACUTE GASTROENTERITIS, VS. PLACEBO, PROBIOTICS, GUIDELINES, MANAGEMENT, STRAINS
  • Eskisehir Osmangazi University Affiliated: Yes


Aim Guidelines consider certain probiotics useful in the management of acute gastroenteritis. This study evaluated the use of Lactobacillus (L) reuteri DSM 17938. Methods A multicentre, randomised, single-blind clinical trial was performed in hospitalised children with acute gastroenteritis lasting 12-72h. Children received conventional therapy with, or without, 1x108CFU of L.reuteri DSM 17938 for 5days. The primary endpoint was the duration of diarrhoea and secondary outcomes were days of hospitalisation and the percentage of children with diarrhoea after each day of treatment. Results We compared 64 children receiving L.reuteri with 63 controls. Lactobacillus reuteri reduced the duration of diarrhoea after 24h (p<0.001) and more diarrhoea-free children were seen in the L.reuteri than control group after 24 and 48h (50% versus 5%, p<0.001) and 72h (69% versus 11%, p<0.001). Lactobacillus reuteri reduced mean hospital stays (4.31 +/- 1.3days versus 5.46 +/- 1.77days, p<0.001). Prolonged diarrhoea occurred in 17% of the controls, but none of the L.reuteri group. No adverse effects were reported. Conclusion Lactobacillus reuteri effectively reduced the duration of acute diarrhoea and hospital stays in children hospitalised with acute gastroenteritis. Outpatient data are now required.