Angiotensin Peptide Levels in Children With Predialysis Chronic Kidney Disease
PEDIATRICS INTERNATIONAL, cilt.68, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/ped.70422
- Dergi Adı: PEDIATRICS INTERNATIONAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Background: The changes in local renin-angiotensin system (RAS), independent of systemic RAS, are suggested to play a role in the pathophysiology of chronic kidney disease (CKD). This study aimed to investigate RAS molecules in children with predialysis CKD and to evaluate their relationship with echocardiographic parameters. Methods: The patients with predialysis CKD (n = 37) and control group (n = 48) were included. Angiotensin-A, angiotensin-2, angiotensin converting enzyme (ACE)-1, ACE-2, angiotensin 1-7 and alamandin levels were determined by ELISA. Echocardiography was performed with M-mode, pulsed wave Doppler, tissue Doppler, and speckle tracking strain. Results: Serum angiotensin peptide levels were similar between patients and controls. Urinary angiotensin peptides were lower in patients and were positively correlated with glomerular filtration rate (p < 0.001 for each). Urinary angiotensin peptides were lower and serum angiotensin-2 and angiotensin 1-7 were higher in patients without hypertension compared to controls (p < 0.05). Serum ACE-2 was lower in patients with hypertension (p < 0.05). Urinary angiotensin peptides and serum angiotensin-A were lower in CKD with hypertension compared to healthy children (p < 0.05). In logistic regression analysis, hypertension was negatively correlated with urinary angiotensin peptides. Serum angiotensin-A was negatively and angiotensin-2 was positively correlated with hypertension (p < 0.05). Mitral lateral E was positively correlated with serum alamandin and ACE-2 (p < 0.05). Tricuspid E/A correlated with serum alamandin, angiotensin-A, ACE-1 and ACE-2 levels (p < 0.05). Tricuspid lateral S was negatively correlated with urinary alamandin and urinary angiotensin-A (p < 0.05). Conclusion: Circulating and local RAS molecules may play a role in renal dysfunction, hypertension, and echocardiographic alteration in children with predialysis CKD.