Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney

ŞENTÜRK H., Kabay S., Bayramoglu G., ÖZDEN H., YAYLAK F., YÜCEL M., ...Daha Fazla

WORLD JOURNAL OF UROLOGY, cilt.26, sa.4, ss.401-407, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00345-008-0256-1
  • Dergi Adı: WORLD JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.401-407
  • Anahtar Kelimeler: renal, ischemia reperfusion injury, silymarin, morphology, ISCHEMIA-REPERFUSION INJURY, INTRACELLULAR CALCIUM, OXIDATIVE STRESS, MILK THISTLE, FAILURE, LIVER, INFILTRATION, FLAVONOIDS, CELLS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objectives Renal ischemia/reperfusion (I/R) injury is associated with increased mortality and morbidity rates due to acute renal failure (ARF). Oxidative stress induced with renal I/R injury directly affects glomerular and tubular epithelium through reactive oxygen species. Several studies have been directed to the treatment of renal I/R injury. The aim of this study was to test the attenuation with silymarin (SM) treatment of renal I/R injury-induced morphological changes in the rat kidney.