Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney


ŞENTÜRK H., Kabay S., Bayramoglu G., ÖZDEN H., YAYLAK F., YÜCEL M., ...More

WORLD JOURNAL OF UROLOGY, vol.26, no.4, pp.401-407, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1007/s00345-008-0256-1
  • Journal Name: WORLD JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.401-407
  • Keywords: renal, ischemia reperfusion injury, silymarin, morphology, ISCHEMIA-REPERFUSION INJURY, INTRACELLULAR CALCIUM, OXIDATIVE STRESS, MILK THISTLE, FAILURE, LIVER, INFILTRATION, FLAVONOIDS, CELLS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objectives Renal ischemia/reperfusion (I/R) injury is associated with increased mortality and morbidity rates due to acute renal failure (ARF). Oxidative stress induced with renal I/R injury directly affects glomerular and tubular epithelium through reactive oxygen species. Several studies have been directed to the treatment of renal I/R injury. The aim of this study was to test the attenuation with silymarin (SM) treatment of renal I/R injury-induced morphological changes in the rat kidney.