Clostridioides difficile Infections: Prevention and Treatment Strategies
Advances in experimental medicine and biology, cilt.1449, ss.175-186, 2024 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 1449
- Basım Tarihi: 2024
- Doi Numarası: 10.1007/978-3-031-58572-2_11
- Dergi Adı: Advances in experimental medicine and biology
- Derginin Tarandığı İndeksler: Scopus, EMBASE
- Sayfa Sayıları: ss.175-186
- Anahtar Kelimeler: Children, Clostridioides (Clostridium) difficile, Prevention, Probiotics, Recurrence, Treatment, Yeast
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary widely from an asymptomatic infection to a lethal disease. While discontinuation of antimicrobial agents and antibiotic treatment of the infection remain the cornerstone of therapy, more recent fecal microbiota transplantation has also been valid as a therapy. The use of probiotics, especially Saccharomyces boulardii CNCM I-745 have become valid forms of prevention therapy. Although there are studies in adults with microbiota-targeted new generation therapies and Clostridium difficile vaccines, there are no data in the paediatric age group yet.