The Importance of Determining the Drug Agent Responsible for Pancytopenia in Patients with Rheumatoid Arthritis and Additional Systemic Diseases

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ÜSKÜDAR TEKE H., Tasdemir A. E., Ozen M.

TURKISH JOURNAL OF RHEUMATOLOGY, cilt.28, sa.2, ss.123-127, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5606/tjr.2013.2808
  • Dergi Adı: TURKISH JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.123-127
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Methotrexate (MTX) is the most commonly used drug in the treatment of rheumatoid arthritis (RA). In MTX-treated RA patients, the prevalence of pancytopenia is nearly 3%. Several medications may be prescribed for RA patients with an additional systemic disease. This may result in bone marrow toxicity, making it difficult to know which drug induced the pancytopenic condition. Therefore, identifying the culprit agent through bone marrow aspiration and biopsy findings of the samples is critical for determining the best course of treatment for pancytopenia. Significantly increased amounts of eosinophilia in the bone marrow indicate that MTX is the culprit for the presentation of pancytopenia.