Evaluation of the systemic antiinflammatory effects of levosimendan in an experimental blunt thoracic trauma model

Ates G., Yaman F., Bakar B., Kisa U., Atasoy P., Buyukkocak U.

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.23, sa.5, ss.368-376, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5505/tjtes.2016.26786
  • Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.368-376
  • Anahtar Kelimeler: Blunt chest trauma, levosimendan, inflammation, lung contusion, nuclear factor-kappa B, BILATERAL LUNG CONTUSION, PULMONARY CONTUSION, CHEST TRAUMA, INJURY, INFLAMMATION, RESPONSES
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

BACKGROUND: Blunt thoracic injury often leads to pulmonary contusion and the development of acute respiratory distress syndrome, which carries a high risk of morbidity and mortality, originating from the local and systemic inflammatory states. This study aimed to investigate the local and systemic antiinflammatory effects of levosimendan in rat models of blunt chest trauma.