Akademik Veri Yönetim Sistemi
Eurasian Journal of Medical Investigation, cilt.8, sa.1, ss.1-7, 2024 (TRDizin)
Objectives: In our study, we aimed to investigate the relation between obesity and haematological toxicities evalu- ated after chemotherapy treatment with lipophilic chemotherapy given according to actual body surface area in breast cancer (Bca) patients with different stages and subtypes and its reflection on overall survival. Methods: 419 patients who received lipophilic chemotherapy regimens as the first serial chemotherapy regimen, who were not treated with primary granulocyte colony-stimulating factor (G-CSF) and whose haematological parameters were evaluated after the first course of treatment were included in the study. Results: It was found that 36.8% of 419 patients included in the study were obese. There was no difference between the groups in baseline clinicopathological characteristics except for age. There was a positive correlation between age and BMI values (r=0.254 p<0.001). Grade 3 and grade 4 neutropenia were observed more frequently in normal/under- weight patients (p<0.05). Multivariate cox regression analysis showed that grade 3 thrombocytopenia affected survival 17.398 and grade 4 thrombocytopenia affected survival 14.004 times more negatively than grade 0 thrombocytopenia (p<0.001, p<0.001, respectively). Conclusion: No increase in toxicity or worsening of survival was observed with lipophilic chemotherapy agents given according to actual BSA in obese BCa patients with different stages and immunohistochemical subtypes. Keywords: Breast cancer, chemotherapy toxicity, obesity, lipophilic agents