Synthesis of Thiophene/Furan-Artemisinin Hybrid Molecules

Ozok-Arici Ö., Kavak E., KIVRAK A.

CHEMISTRY & BIODIVERSITY, vol.19, no.8, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.1002/cbdv.202200144
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: artemisinin, furan, natural products, thiophene, wormwood plant, ANTIMALARIAL, DIHYDROARTEMISININ, DERIVATIVES, DISCOVERY
  • Eskisehir Osmangazi University Affiliated: Yes


Natural products with semi-synthetic molecules displays higher biological activities, and creates new biological properties for the treatment of diseases. Although, natural products like artemisinin have been used as a traditional medicine over thousands of years, structure and biological properties of many natural products were investigated in the 20th century. Design and synthesis of new biologically active compounds including natural products have very critical roles to find novel drug candidates. Herein, novel thiophene/furan bridge artemisinin derivatives were synthesized by starting from artemisinin. Firstly, benzothiophene derivatives are synthesized, then Steglich esterification reactions give the new artemisinin hybrid molecules with moderate to high yields.