The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle


Guneysu E., Kocman A. E. , Ozatik O., OVALI C., CAN B., ALATAŞ İ. Ö. , ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.3, pp.1028-1036, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1604-59
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1028-1036
  • Keywords: Ischemia, reperfusion injury, iloprost, alprostadil, skeletal, muscle, PROSTAGLANDIN E-1, ISCHEMIA/REPERFUSION INJURY, LIMB, ADHESION, SURGERY, MODEL
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background/aim: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury.