Central nervous system malformations and contributing disorders

Yimenicioglu S., Yakut A., Ekici A., YARAR C., ÇARMAN K. B. , Kocak O., ...More

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol.9, no.9, pp.18151-18159, 2016 (SCI-Expanded) identifier


Purpose: Neurologic disorders may be seen in patients with cerebral malformations. The aim of this study is determining epilepsy and the other contributing disorders in the patients with cerebral malformations using Gross Motor Function Classification Scale (GMFCS) and Bimanual Fine Motor Function Scale (BFMFS) are used to determine motor function. Methods: The clinical and neuroradiologic features of 76 patients with cerebral malformations admitted between the dates December 2011 and May 2012 were evaluated and motor prognosis is determined. Result: The most common associated disorders were mental retardation, epilepsy, language and speech disorders, malnutrition, Cerebral Palsy. Epilepsy was seen at half of the patients, and it was most common in cerebral cortex malformations (P<0.05). GMFCS level 5 was most common associated with cerebral cortex malformations. Most of the patients with cerebral palsy had GMFCS level 5. Oromotor dysfunction was most common in cerebral cortex malformations. Patients' developmental state and oromotor function got worse with increasing GMFCS level. Epileptic patients had higher GMFCS and BFMFS levels than others. Conclusion: Central nervous system malformations are frequently associated with epilepsy and mental retardation, there were severe neurologic findings in these patients. We concluded that GMFCS and BFMFS may be beneficial to determine the motor prognosis in these patients.