Clinical, laboratory features and prognosis of children receiving IgM-enriched immunoglobulin (3 days vs. 5 days) as adjuvant treatment for serious infectious disease in pediatric intensive care unit: a retrospective single-center experience (PIGMENT study).

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Abdullayev E., KILIÇ Ö., BOZAN G., Kiral E., Iseri Nepesov M., DİNLEYİCİ E. Ç.

Human vaccines & immunotherapeutics, vol.16, no.8, pp.1997-2002, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.1080/21645515.2019.1711298
  • Journal Name: Human vaccines & immunotherapeutics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.1997-2002
  • Keywords: IgM-enriched intravenous immunoglobulin, sepsis, septic shock, children, SEPTIC SHOCK, INTRAVENOUS IMMUNOGLOBULIN, SEVERE SEPSIS, POLYCLONAL IMMUNOGLOBULIN, ADJUNCTIVE THERAPY, CYTOKINES, ENDOTOXIN, SURVIVAL, MODEL
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Introduction: Although there are studies about sepsis treatment in different age groups, data on immunoglobulin-M (IgM)-enriched intravenous immunoglobulin use in pediatric intensive care units (PICUs) are limited. The aim of this study was to evaluate the clinical features and prognoses of children receiving IgM-enriched intravenous immunoglobulin to treat sepsis, septic shock, and multi-organ failure. Method: We extracted data from the medical records of 254 children who received IgM-enriched intravenous immunoglobulin infusion (104 children for 3 days, 150 children for 5 days) in addition to standard treatment between 2010 and 2017. Results: When the 5-day vs. 3-day IgM-enriched immunoglobulin treatments were compared, the mortality rate was shown to be lower in patients who received the longer duration of treatment (p < .001). Better outcomes were observed among children with septic shock (p ). Conclusion: Our clinical work with 5-days IgM-enriched intravenous immunoglobulin may reveal a survival benefit of this treatment for children with septic shock.