Comparison of Hippocampal Volume Measured Using Magnetic Resonance Imaging in Alzheimer's Disease, Vascular Dementia, Mild Cognitive Impairment and Pseudodementia

Dolek N., Saylisoy S., Ozbabalik D., Adapinar B.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.40, sa.2, ss.717-725, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/147323001204000236
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.717-725
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

OBJECTIVE: To examine the relationship between different types of dementia and hippocampal volume. METHODS: Hippocampal volume was measured by magnetic resonance imaging in patients with Alzheimer's disease (n = 22), vascular dementia (n = 14), mild cognitive impairment (n = 12) or pseudodementia (n = 16), and in healthy control subjects (n = 11). The Mini Mental State Examination was used to stratify subjects according to cognitive function. RESULTS: Hippocampal volume was reduced by 42% in Alzheimer's disease, 21% in vascular dementia, 15% in mild cognitive impairment and 13% in pseudodementia compared with controls. The severity of dementia increased in line with decreasing hippocampal volume. CONCLUSIONS: Measurement of hippocampal volume may facilitate differentiation between dementia subtypes. There was a relationship between reduced hippocampal volume and the degree of cognitive impairment.