Effects of Colistin Sulphate, Tigecycline, and Cefoperazone-Sulbactam on the Multi-Drug Resistant Acinetobacter baumannii Experimental Mouse Sepsis Model

Creative Commons License

Temur E., DİNLEYİCİ E. Ç., Tekin R. T., Kiremitci A., SIRMAGÜL B., Yargic Z. A., ...Daha Fazla

JOURNAL OF PEDIATRIC INFECTION, cilt.9, sa.1, ss.25-33, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/ced.2015.1957
  • Dergi Adı: JOURNAL OF PEDIATRIC INFECTION
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.25-33
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Incidence of Acinetobacter infections is increasing both in Turkey and worldwide. Based on their ability to develop resistance, Acinetobacter species can cause morbidity and mortality, particularly in newborns, children, immunocompromised patients, and critically ill intensive care patients. There are limited treatment options, particularly in carbapenem resistant Acinetobacter strains. In this study, we aimed to compare in vivo activities of colistin sulphate, tigecycline, and cefoperazone-sulbactam in an experimental mouse sepsis model.