Effects of Colistin Sulphate, Tigecycline, and Cefoperazone-Sulbactam on the Multi-Drug Resistant Acinetobacter baumannii Experimental Mouse Sepsis Model

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Temur E., DİNLEYİCİ E. Ç., Tekin R. T., Kiremitci A., SIRMAGÜL B., Yargic Z. A., ...More

JOURNAL OF PEDIATRIC INFECTION, vol.9, no.1, pp.25-33, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5152/ced.2015.1957
  • Journal Name: JOURNAL OF PEDIATRIC INFECTION
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.25-33
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Incidence of Acinetobacter infections is increasing both in Turkey and worldwide. Based on their ability to develop resistance, Acinetobacter species can cause morbidity and mortality, particularly in newborns, children, immunocompromised patients, and critically ill intensive care patients. There are limited treatment options, particularly in carbapenem resistant Acinetobacter strains. In this study, we aimed to compare in vivo activities of colistin sulphate, tigecycline, and cefoperazone-sulbactam in an experimental mouse sepsis model.