Pregabalin Attenuates Carrageenan-Induced Acute Inflammation in Rats by Inhibiting Proinflammatory Cytokine Levels
EURASIAN JOURNAL OF MEDICINE, cilt.50, ss.156-159, 2018 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50
- Basım Tarihi: 2018
- Doi Numarası: 10.5152/eurasianjmed.2018.17261
- Dergi Adı: EURASIAN JOURNAL OF MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.156-159
- Anahtar Kelimeler: Pregabalin, inflammation, anti-inflammatory effect, cytokines, rat, HYPERSENSITIVITY, GABAPENTIN, MECHANISMS, EXTRACT, MODELS, ACID, MICE
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats.