Pregabalin Attenuates Carrageenan-Induced Acute Inflammation in Rats by Inhibiting Proinflammatory Cytokine Levels

Kılıç F. S., Kaygısız B., Aydın Ş., Yildirim C., Karimkhani H., Oner S.

EURASIAN JOURNAL OF MEDICINE, cilt.50, ss.156-159, 2018 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/eurasianjmed.2018.17261
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.156-159
  • Anahtar Kelimeler: Pregabalin, inflammation, anti-inflammatory effect, cytokines, rat, HYPERSENSITIVITY, GABAPENTIN, MECHANISMS, EXTRACT, MODELS, ACID, MICE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats.