Carvacrol attenuates cyclophosphamide-induced oxidative stress in rat kidney

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GÜNEŞ S., AYHANCİ A., ŞAHİNTÜRK V., Altay D. U., Uyar R.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, cilt.95, sa.7, ss.844-849, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1139/cjpp-2016-0450
  • Dergi Adı: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.844-849
  • Anahtar Kelimeler: cyclophosphamide, carvacrol, nephrotoxicity, oxidative stress, cytoprotection, INDUCED HEMORRHAGIC CYSTITIS, INDUCED NEPHROTOXICITY, INDUCED LUNG, TOXICITY, INJURY, DAMAGE, APOPTOSIS, ACROLEIN, EXTRACT, THYMOL
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Cyclophosphamide (CP) is an antineoplastic drug that induces kidney damage via producing oxidative stress. Carvacrol (CAR) has antioxidative effect and we postulated that it can be protective against CP-induced nephrotoxicity. Six groups (n = 7) of rats (control, 100 mg/kg CP, CP+5 mg/kg CAR, CP+10 mg/kg CAR, 5 mg/kg CAR, and 10 mg/kg CAR) were injected intraperitoneally. Serum malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), creatinine (CRE), total antioxidant capacity (TAC), and total oxidant state (TOS) were measured, and oxidative stress indexes (OSI) were calculated. Kidneys were also analyzed histologically. In CP-alone group MDA, CRE, TOS, and OSI levels increased whereas GSH, SOD, CAT, and TAC levels decreased compared with control group. In CP plus CAR groups, MDA, TOS, and OSI levels decreased whereas GSH, SOD, CAT, and TAC levels increased compared with CP-alone group. However, CRE levels were similar in CP-alone and CP+5 CAR group whereas decreased in CP+10 CAR group. CP+10 CAR group was significantly different in all parameters (except TAC) from CP+5 CAR group. Kidney microscopy was showed lower tissue damage in CP plus CAR groups. In conclusion, 10 mg/kg CAR is more effective than 5 mg/kg CAR in prevention of CP-induced oxidative damage on kidney.