Hepatotoxicity and nephrotoxicity following long-term prenatal exposure of paracetamol in the neonatal rat: is betaine protective?

Ozkoc M., Karimkhani H., KANBAK G., BURUKOĞLU DÖNMEZ D.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.1, pp.99-107, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1515/tjb-2018-0307
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.99-107
  • Keywords: Paracetamol, Pregnancy, Paraoxonase, Arylesterase, Betaine, OXIDATIVE STRESS, ACETAMINOPHEN, PARAOXONASE, INHIBITION, ACETATE, INJURY, SERUM, MODEL
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Paracetamol is one of the widely used antipyretic and analgesic drug around the world. Many researchers showed that paracetamol caused to hepato-toxicity or nephrotoxicity.