Hepatotoxicity and nephrotoxicity following long-term prenatal exposure of paracetamol in the neonatal rat: is betaine protective?

Ozkoc M., Karimkhani H., KANBAK G., BURUKOĞLU DÖNMEZ D.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.45, sa.1, ss.99-107, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2018-0307
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.99-107
  • Anahtar Kelimeler: Paracetamol, Pregnancy, Paraoxonase, Arylesterase, Betaine, OXIDATIVE STRESS, ACETAMINOPHEN, PARAOXONASE, INHIBITION, ACETATE, INJURY, SERUM, MODEL
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Paracetamol is one of the widely used antipyretic and analgesic drug around the world. Many researchers showed that paracetamol caused to hepato-toxicity or nephrotoxicity.