Evaluation of 334 paediatric chronic non-bacterial osteomyelitis cases: A multicentre cohort study defining clusters

BAŞARAN, HALİDE; Bayındır, Yağmur; DEMİR, SELCAN; YILDIZ, ADALET; Aliyev, Emil; Ulu, Kadir; Kayhan, Eda; Haşlak, Fatih; Akgün, Özlem; Aydın, Elif; İsgüder, Rana; Tekin, Zahide; Köse, Hülya; Baba, Özge; Karaçayır, Nihal; Ayduran, Semra; Ay, Elif; KAYA AKCA, ÜMMÜŞEN; Dündar, Hatice; Cüceoğlu, Müşerref; Çağlayan, Şengül; Bülbül, Aydan; Varol, Şevki; Batu, Ezgi; Bora, Balahan; SÖNMEZ, HAFİZE; Öztürk, Kübra; Gürgöze, Metin; YÜKSEL, SELÇUK; KALYONCU, MUKADDES; Bakkaloğlu, Sevcan; KILIÇ GÜLTEKİN, SARA; Çakan, Mustafa; Ekinci, Rabia; ÜNSAL, ŞEVKET; Özdel, Semanur; ÇELİKEL ACAR, Banu; Ayaz, Nuray; KASAPÇOPUR, ÖZGÜR; Kısaarslan, Ayşenur; SÖZERİ, Betül; Bilginer, Yelda; Özen, Seza

doi:10.1093/mr/roag019

Evaluation of 334 paediatric chronic non-bacterial osteomyelitis cases: A multicentre cohort study defining clusters

BAŞARAN H. Ö., Bayındır Y., DEMİR S., YILDIZ A. E., Aliyev E., Ulu K., ...Daha Fazla

Modern rheumatology, cilt.36, sa.5, ss.845-851, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 36 Sayı: 5
Basım Tarihi: 2026
Doi Numarası: 10.1093/mr/roag019
Dergi Adı: Modern rheumatology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
Sayfa Sayıları: ss.845-851
Anahtar Kelimeler: autoinflammatory bone disease, chronic non-bacterial osteomyelitis, Chronic recurrent osteomyelitis, cluster, paediatric
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

OBJECTIVES: This multicentre cohort study aimed to describe the clinical and demographic features of paediatric patients diagnosed with chronic non-bacterial osteomyelitis in Turkey and to identify patient clusters based on bone involvement. METHODS: A total of 334 paediatric chronic non-bacterial osteomyelitis patients from 21 paediatric rheumatology centres were included. Data on clinical presentation, imaging, and biopsy results were collected. A two-step cluster analysis was performed to classify patients by bone-site involvement, resulting in four distinct clusters. RESULTS: Axial-thoracic cluster, involving the vertebra, clavicle, and sternum, was more common in female patients and showed higher rates of skin involvement. Lower-extremity cluster, characterized by lower extremity bone involvement, included the largest number of patients. Unlike previous reports, the Turkish cohort had a higher proportion of male patients and a lower frequency of skin involvement. At a median follow-up of 42.4 months, 77.3% of patients achieved remission, while 22% experienced a relapse. Mandibular involvement, additional rheumatologic diseases, and localized bone pain were associated with an increased relapse risk. CONCLUSIONS: This study highlights the clinical profile of paediatric chronic non-bacterial osteomyelitis in Turkey, marked by male predominance and low skin involvement. The identified bone-site clusters may help guide prognosis and should be validated in other populations.