Investigation of uroprotective effects of seed methanol extracts of Hypericum triquetrifolium Turra. on cyclophosphamide-induced bladder hemorrhagic cystitis and nephrotoxicity in Wistar albino rats

Yildiz, Songul; Keskin, Cumali; Şahintürk, VAROL; Ayhanci, ADNAN

doi:10.17826/cumj.730817

Investigation of uroprotective effects of seed methanol extracts of Hypericum triquetrifolium Turra. on cyclophosphamide-induced bladder hemorrhagic cystitis and nephrotoxicity in Wistar albino rats

Yildiz S. C., Keskin C., Şahintürk V., Ayhanci A.

CUKUROVA MEDICAL JOURNAL, cilt.45, sa.4, ss.1361-1371, 2020 (ESCI, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 4
Basım Tarihi: 2020
Doi Numarası: 10.17826/cumj.730817
Dergi Adı: CUKUROVA MEDICAL JOURNAL
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.1361-1371
Anahtar Kelimeler: Cyclophosphamide, Hypericum triquetrifolium, nephrotoxicity, hemorrhagic cystitis, OXIDATIVE STRESS, DAMAGE, ASSOCIATION, ANTIOXIDANT, CHEMOTHERAPY, UROTOXICITY, ANTAGONIST, EXPRESSION, RECEPTORS, MORTALITY
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats.