Investigation of uroprotective effects of seed methanol extracts of Hypericum triquetrifolium Turra. on cyclophosphamide-induced bladder hemorrhagic cystitis and nephrotoxicity in Wistar albino rats

Yildiz S. C., Keskin C., Şahintürk V., Ayhanci A.

CUKUROVA MEDICAL JOURNAL, vol.45, no.4, pp.1361-1371, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.17826/cumj.730817
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1361-1371
  • Keywords: Cyclophosphamide, Hypericum triquetrifolium, nephrotoxicity, hemorrhagic cystitis, OXIDATIVE STRESS, DAMAGE, ASSOCIATION, ANTIOXIDANT, CHEMOTHERAPY, UROTOXICITY, ANTAGONIST, EXPRESSION, RECEPTORS, MORTALITY
  • Eskisehir Osmangazi University Affiliated: Yes


Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats.