ARTHRITIS AND RHEUMATISM, vol.56, no.12, pp.3959-3967, 2007 (SCI-Expanded)
Objective. Normal synovial lining is composed of macrophage-like type A and fibroblast-like type B lining cells. This sheet-like structure lacks a basement membrane, but its intercellular substance contains some basement membrane components, including type IV collagen. We undertook this study to determine the a-chain composition of type IV collagen in normal and arthritic synovial lining, using monoclonal a-chain antibodies.