Type IV collagen alpha-chain composition in synovial lining from trauma patients and patients with rheumatoid arthritis

Creative Commons License

Poduval P., Sillat T., Beklen A., Kouri V. P., Virtanen I., Konttinen Y. T.

ARTHRITIS AND RHEUMATISM, vol.56, no.12, pp.3959-3967, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 12
  • Publication Date: 2007
  • Doi Number: 10.1002/art.23072
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3959-3967
  • Eskisehir Osmangazi University Affiliated: No


Objective. Normal synovial lining is composed of macrophage-like type A and fibroblast-like type B lining cells. This sheet-like structure lacks a basement membrane, but its intercellular substance contains some basement membrane components, including type IV collagen. We undertook this study to determine the a-chain composition of type IV collagen in normal and arthritic synovial lining, using monoclonal a-chain antibodies.