Type IV collagen alpha-chain composition in synovial lining from trauma patients and patients with rheumatoid arthritis


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Poduval P., Sillat T., Beklen A., Kouri V. P., Virtanen I., Konttinen Y. T.

ARTHRITIS AND RHEUMATISM, vol.56, no.12, pp.3959-3967, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 12
  • Publication Date: 2007
  • Doi Number: 10.1002/art.23072
  • Journal Name: ARTHRITIS AND RHEUMATISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3959-3967
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Objective. Normal synovial lining is composed of macrophage-like type A and fibroblast-like type B lining cells. This sheet-like structure lacks a basement membrane, but its intercellular substance contains some basement membrane components, including type IV collagen. We undertook this study to determine the a-chain composition of type IV collagen in normal and arthritic synovial lining, using monoclonal a-chain antibodies.