Retrospective evaluation of 25 cases diagnosed to have vulvar intraepithelial neoplasia Vulvar intraepiteliyal neoplazi tanisi alan 25 olgunun retrospektif degerlendirilmesi

Ozalp S., YALÇIN Ö. T., Bayirli R., Yildirim A.

Jinekoloji ve Obstetri Bulteni, vol.6, no.4, pp.147-152, 1997 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 4
  • Publication Date: 1997
  • Journal Name: Jinekoloji ve Obstetri Bulteni
  • Journal Indexes: Scopus
  • Page Numbers: pp.147-152
  • Eskisehir Osmangazi University Affiliated: Yes


Objective: To evaluate the cases diagnosed to have vulvar intraepithelial neoplasia (VIN) retrospectively. Study design: Patients, who applied with the complaint of vulvar pruritus, were evaluated by colposcopic inspection and toluidin test. Biopsies were taken from the areas which had positive toluidin test or suspicious lesions under colposcopic observation. Results: Biopsies were taken from 100 (58.0%) of the 172 cases with vulvar pruritus. Twenty-five (25.0%) of 100 cases who were biopsied, were diagnosed to have VIN's, including 18 patients with VIN I, 5 with VIN II and 2 with VIN III. Seventeen (68.0%) of the 25 cases with VIN were in premenopausal period, while 10 (40.0%) of them were under 40 years of age. VIN's were multifocal in 17 (68.0%) cases and synchronized cervical intraepithelial neoplasias (CIN) were diagnosed in 3 (12.0%) cases. Although 4 cases did not accept any treatment, skinning vulvectomy were performed in 13, skinning vulvectomy and skin graft were performed in 5 and simple vulvectomy were performed in 3 patients. During the postoperative follow up, recurrences were detected near the skin graft in 2 patients who had skinning vulvectomy and skin graft, while no cosmetic problem or sexual dysfunction was noted. Conclusion: It was considered that biopsy under colposcopic observation and toluidin test was an effective method for the diagnosis of VIN. Surgical methods which did not create sexual dysfunction could be used effectively for the treatment of VINs most of which were multicentric and developed during the reproductive period. However these cases should be evaluated for synchronized CIN, and followed closely for recurrences.