Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

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ALTINTOP M. D., Abu Mohsen U., KARACA GENÇER H., CANTÜRK Z., ÖZDEMİR A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.11, no.10, pp.1199-1203, 2014 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 11 Issue: 10
• Publication Date: 2014
• Doi Number: 10.2174/1570180811666140717185937
• Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1199-1203
• Eskisehir Osmangazi University Affiliated: No

Abstract

In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole- 1-(4-(4-methoxyphenyl) thiazol-2-yl)] (3d) showed notable antimicrobial activity.