Role of the AZFd locus in spermatogenesis.

Muslumanoglu M., Turgut M., Cilingir O., Can C., Ozyurek Y., Artan S.

Fertility and sterility, cilt.84, sa.2, ss.519-22, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.fertnstert.2005.02.024
  • Dergi Adı: Fertility and sterility
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.519-22
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

To determine the prevalence of Y-chromosome microdeletions among infertile men and to correlate the clinical presentation of the men with specific deletions, microdeletion analysis in 53 infertile men (30 nonobstructive azoospermic, 23 severely oligozoospermic patients), and 100 age-matched, fathered normospermic men who had fathered children was performed by the multiplex PCR with 18 different Y-chromosome-specific STS primer sets, spanning the AZFa, AZFb, AZFd, and AZFc regions. Detection of the same locus deletion of the AZFd region in three cases indicated the possible importance of the genes located in this region in spermatogenesis.