Novel and Efficient Methods for the Synthesis of Symmetrical Trisulfides

Kertmen A., Lach S., Rachon J., Witt D.

SYNTHESIS-STUTTGART, no.9, pp.1459-1462, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1055/s-0028-1088161
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1459-1462
  • Eskisehir Osmangazi University Affiliated: Yes


We have developed convenient methods for the synthesis of symmetrical trisulfides under mild conditions in very good yields. The described methods are based oil the straightforward preparation of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorin-2-yl)disulfanyl derivatives from readily available 5,5-dimethyl-2-sulfanyl-2-thioxo-1,3,2-dioxaphosphorinane or bis(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl) disulfide. The symmetrical trisulfides can be obtained from aliphatic and aromatic thiols and also L-cysteine derivatives.