Sodium-glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology

Seferovic P. M., Fragasso G., Petrie M., Mullens W., Ferrari R., Thum T., ...Daha Fazla

EUROPEAN JOURNAL OF HEART FAILURE, cilt.22, sa.9, ss.1495-1503, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ejhf.1954
  • Dergi Adı: EUROPEAN JOURNAL OF HEART FAILURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1495-1503
  • Anahtar Kelimeler: Heart failure, Sodium-glucose co-transporter 2 inhibitors, Type 2 diabetes mellitus, Cardiovascular outcomes, Quality of life, SERUM URIC-ACID, CARDIOVASCULAR OUTCOMES, SGLT2 INHIBITORS, DIABETES-MELLITUS, KIDNEY-DISEASE, EMPAGLIFLOZIN, MECHANISM, DAPAGLIFLOZIN, RESISTANCE, RATIONALE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Heart failure (HF) is common and associated with a poor prognosis, despite advances in treatment. Over the last decade cardiovascular outcome trials with sodium-glucose co-transporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus have demonstrated beneficial effects for three SGLT2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) in reducing hospitalisations for HF. More recently, dapagliflozin reduced the risk of worsening HF or death from cardiovascular causes in patients with chronic HF with reduced left ventricular ejection fraction, with or without type 2 diabetes mellitus. A number of additional trials in HF patients with reduced and/or preserved left ventricular ejection fraction are ongoing and/or about to be reported. The present position paper summarises recent clinical trial evidence and discusses the role of SGLT2 inhibitors in the treatment of HF, pending the results of ongoing trials in different populations of patients with HF.