Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation


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YURTTAŞ L., ÖZKAY Y., KARACA GENÇER H., Acar U.

JOURNAL OF CHEMISTRY, vol.2015, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 2015
  • Publication Date: 2015
  • Doi Number: 10.1155/2015/464379
  • Title of Journal : JOURNAL OF CHEMISTRY

Abstract

New 2-(4-arylpiperazine-1-yl)-N-[4-(2-(4-substituted phenyl)thiazol-4-yl)phenyl]acetamide derivatives were synthesized and evaluated for their antimicrobial and anticholinesterase activities. Acetylcholinesterase inhibitory activities of the compounds were found weak contrary to expectations. It is unlikely that antifungal activity of the compounds was found significant, especially against Candida parapsilosis.