Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

ÖZDEMİR, AHMET; Turan-Zitouni, Guelhan; KAPLANCIKLI, ZAFER; Revial, Gilbert; DEMİRCİ, FATİH; Iscan, Goekalp

doi:10.3109/14756360903373368

Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

Atıf İçin Kopyala

ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A., Revial G., DEMİRCİ F., Iscan G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, sa.4, ss.565-571, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 25 Sayı: 4
Basım Tarihi: 2010
Doi Numarası: 10.3109/14756360903373368
Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.565-571
Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.