Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

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ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A., Revial G., DEMİRCİ F., Iscan G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.25, no.4, pp.565-571, 2010 (SCI-Expanded) identifier identifier identifier


The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.