Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis

Bilgili M. E., SARAÇOĞLU Z. N., Yildiz H., Aslan A., Sabuncu I.

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, vol.6, no.1, pp.37-40, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4328/jcam.1746
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.37-40
  • Keywords: Tinea Pedis, Terbinafine, Itraconazole, 250 MG/DAY, PREVALENCE
  • Eskisehir Osmangazi University Affiliated: Yes


Aim:The aim of this study was to evaluate the efficacy and safety of oral terbinafine and itraconazole in the treatment of the patients with interdigital tinea pedis. Material and Method:A total 60 patients with clinically and mycologically diagnosed as interdigital tinea pedis were enrolled to the study. Patients were divided into two groups. The first group received oral terbinafine 250 mg/day for two weeks (n:30). The second group received itraconazole 200 mg daily for 7 days (n:30). At the first visit and 15, 30, 60 days after the start of the study, signs and symptoms were assessed clinically and scales were taken for mycological assessments. Results:Six patients who did not return after the first visit were excluded from the study (2 on terbinafine, 4 on itraconazole). The effectiveness of therapy was evaluated at day 15, 30, 60. Symptoms were absent in 57.1% of terbinafine group and 46.1% of the itraconazole group in the first control. The effectiveness of the terbinafine group was 82.1% and 73.1% of the itraconazole group in second control. At day 60, the cure rates were similar (89.3% for terbinafine, 84.6% for itraconazole). No statistical significant differences between the two groups was observed (p>0.05). Discussion:Oral terbinafine and itraconazole have the same effectiveness and tolerability in the treatment of interdigital tinea pedis.