Hemi-meningitis with hemophagocytic lymphohistiocytosis

Kocak O., YARAR C., Yimenicioglu S., Ekici A., BÖR Ö.

ANNALS OF INDIAN ACADEMY OF NEUROLOGY, cilt.19, sa.3, ss.388-391, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4103/0972-2327.165458
  • Dergi Adı: ANNALS OF INDIAN ACADEMY OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.388-391
  • Anahtar Kelimeler: Epstein-Barr virus, hemi-meningitis, hemophagocytic lymphohistiocytosis, hemophagocytic syndrome, EPSTEIN-BARR-VIRUS, CHILDREN, INVOLVEMENT
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Hemophagocytic lymphohistiocytosis (HLH) is a rare lymphoproliferative disorder. HLH may occur as a complication of Epstein-Barr virus (EBV), particularly in patients with immunodeficiencies. Herein, we describe a 16-year-old girl with neurological complications associated EBV-induced HLH. Her cerebral magnetic resonance imaging (MRI) showed contrast-enhanced axial T1-weighted images with enhancement of meningeal surface in the right hemisphere that was consistent with right hemi-meningitis. Hydrocephalus, dilated subdural spaces, delayed myelination, edema, diffuse parenchymal atrophy, calcifications, diffuse/patchy white matter abnormalities have all been previously described with HLH. To the best of our knowledge, this is the first case of hemi-meningitis associated with HLH. We suggest that clinicians should consider HLH with vascular disorders when they determine unilateral meningitis on a brain MRI.