Trauma is tissue damage caused by an extrinsic force. The stress response comprises an activation of neurohumoral and physiologic process that would lead to improved survivability of an untreated organism following a traumatic injury. The sequelae of inadequate pain control following an injury are more than physiological. Chronic neuropathic pain is a frequent sequelae of trauma. Trauma and burn victims usually have poor pain management, because of the fear of hemodynamic alterations and respiratory depression. Early or even preemptive treatment of pain have been shown to reduce analgesic requirements over time. Individual patients will have widely variant requirements for pain medications, so induction of analgesia must be carefully adjusted, ideally in a closely monitored environment. Pharmacotherapy and interventional methods can be used in a wide variety for the management of pain in trauma and burns.