MDR1,MRP1 and LRP expression in patients with untreated acute leukaemia: Correlation with Tc-99m-MIBI bone marrow scintigraphy

Ak Y., Demirel G., Gulbas Z.

NUCLEAR MEDICINE COMMUNICATIONS, vol.28, no.7, pp.541-546, 2007 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 7
  • Publication Date: 2007
  • Journal Name: NUCLEAR MEDICINE COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.541-546
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Background Chemotherapy failure linked to multidrugresistance (MDR) plays an important role in many cancer types, including leukaemia. It is believed that overexpression of some of membrane or intracellular proteins confers the MDR phenotype to cancer cells. Tc-99m-sestarnibi (M 1130 is a transport substrate for the Pgp pump. We assessed the bone marrow uptake of Tc-99m-MIBI and its correlation with messenger RNA (mRNA) levels of MDR,, multidrug-resistance associated protein-1 (MRP1) and lung resistance protein (LRP) in acute leukaemia.