Comparative Analyses of Immunosuppressive Characteristics of Bone-Marrow, Wharton's Jelly, and Adipose Tissue-Derived Human Mesenchymal Stem Cells

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Karaoz E., Demircan P. C., Erman G., Gungorurler E., EKER SARIBOYACI A.

TURKISH JOURNAL OF HEMATOLOGY, cilt.34, sa.3, ss.213-225, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjh.2016.0171
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.213-225
  • Anahtar Kelimeler: Immunoregulatory effect, Co-culture, Mesenchymal stem cells, T cells, T-CELLS, DENTAL-PULP, PROLIFERATION, LYMPHOCYTES, SUPPRESS, PROMOTE, INTERLEUKIN-6, EXPRESSION, MIG
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Mesenchymal stem cells (MSCs), which possess immunosuppressive characteristics on induced T-cells, were shown to be applicable in prevention and treatment of graft-versus-host disease. However, knowledge of effective cell sources is still limited. In this study, MSCs from different human tissues, i.e. bone marrow (BM), Wharton's jelly (WJ), and adipose tissue, were isolated, and the immune suppression of stimulated T cells was analyzed comparatively.