Comparative Analyses of Immunosuppressive Characteristics of Bone-Marrow, Wharton's Jelly, and Adipose Tissue-Derived Human Mesenchymal Stem Cells

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Karaoz E., Demircan P. C., Erman G., Gungorurler E., EKER SARIBOYACI A.

TURKISH JOURNAL OF HEMATOLOGY, vol.34, no.3, pp.213-225, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.4274/tjh.2016.0171
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.213-225
  • Keywords: Immunoregulatory effect, Co-culture, Mesenchymal stem cells, T cells, T-CELLS, DENTAL-PULP, PROLIFERATION, LYMPHOCYTES, SUPPRESS, PROMOTE, INTERLEUKIN-6, EXPRESSION, MIG
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Mesenchymal stem cells (MSCs), which possess immunosuppressive characteristics on induced T-cells, were shown to be applicable in prevention and treatment of graft-versus-host disease. However, knowledge of effective cell sources is still limited. In this study, MSCs from different human tissues, i.e. bone marrow (BM), Wharton's jelly (WJ), and adipose tissue, were isolated, and the immune suppression of stimulated T cells was analyzed comparatively.