New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

YURTTAŞ L., KAPLANCIKLI Z. A., Gorgulu-Kahyaoglu S.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.8, pp.910-917, 2017 (SCI-Expanded) identifier identifier


Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis in some tumour models.