C-erb-b2 expression in luminal b breast cancer has higher axillary lymph node involvement ratio


Degirmencioglu G., Kafadar M. T., KILIÇ M.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.13, no.8, pp.845-849, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.4328/acam.21121
  • Journal Name: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.845-849
  • Keywords: Involvement, Axillary Lymph Node, Breast Cancer, PATHOLOGICAL PROGNOSTIC-FACTORS, LYMPHOVASCULAR INVASION, SUBTYPES, RISK
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Aim: In this study, the effect of c-erb-B-2 (HER-2/neu) expression on axillary lymph node involvement in Luminal-B breast cancer was examined. Material and Methods: One hundred seven female patients were included in this study who were classified as Stage 1, Stage 2 and Stage 3 pathologically, with positive Estrogen (ER) and Progesterone Receptor (PR) and with the diagnosis of invasive ductal carcinoma with a single focal mass and not a synchronous tumour and received surgical therapy. The lymph node involvement ratio (LNIR) was divided into two groups as over and below 25%. These acquired data were compared with the groups with positive and negative c-erbB-2 gene expression, axillary LNI status, and LNIR separately. Results: The data of 107 female patients aged between 27 and 87 years were evaluated in this study. The mean age of the patients was 55.69 +/- 12.68 years. LNIR was found to be less than 25% in 76.6% (n: 82) of the patients, and over 25% in 23.4% (n: 25) of the patients. The c-erbB-2 positivity was significantly different in the axilla with and without metastatic lymphadenopathy (p =0.026). There was no statistically significant relationship between tumour diameter and metastatic lymphadenopathy. Although axillary metastatic lymphadenopathy positivity was found to be significant in patients with lymphovascular invasion (p<0.001), it was also found to be significant, as in the group with LNIR>25 (p<0.001). Discussion: This study demonstrated that high expression of c-erbB-2 is associated with poor prognosis of breast cancer by increasing axillary LNI. In hormone (Estrogen and Progesterone) positive patients, if c-erB-2 is also positive, there is greater number of axillary LNI.