Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study

Yilmaz Ş., Demirci N. Y., Metintas S., Zamani A., Karadag M., Guçlu O. A., ...Daha Fazla

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, cilt.63, sa.3, ss.238-243, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1097/jom.0000000000002115
  • Dergi Adı: JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Environment Index, MEDLINE, Pollution Abstracts, Public Affairs Index
  • Sayfa Sayıları: ss.238-243
  • Anahtar Kelimeler: ALK, asbestos, EGFR, Genetic alterations, Lung adenocarcinoma, ROS1, ANAPLASTIC LYMPHOMA KINASE, FACTOR RECEPTOR-MUTATIONS, TARGETED THERAPY, CANCER, ASSOCIATION, SMOKING, CLASSIFICATION, EPIDEMIOLOGY, EXPRESSION, SOCIETY
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.