Synthesis of Novel Benzothiophene Derivatives via Cyclization Reactions

Hama A., Algso M., Kavak E., Kivrak A.

Russian Journal of Organic Chemistry, cilt.56, sa.7, ss.1272-1278, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1134/s1070428020070222
  • Dergi Adı: Russian Journal of Organic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.1272-1278
  • Anahtar Kelimeler: benzothiophenes, heteroaromatic compounds, cyclization reactions, coupling reactions, POLYMER
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

© 2020, Pleiades Publishing, Ltd.Abstract: The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.