Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats

Gulec S., Aydin Y., UZUNER K., Yelken B., Senturk Y.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.21, sa.3, ss.205-209, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1017/s0265021504003072
  • Dergi Adı: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.205-209
  • Anahtar Kelimeler: local anaesthetics, bupivacaine, ropivacaine, cardiovascular agents, clonidine, drug toxicity, SELECTIVE ALPHA(2)-ADRENERGIC AGONIST, LOCAL-ANESTHETICS, CARDIAC RESUSCITATION, REGIONAL ANESTHESIA, CYTOSOLIC CA-2+, CONTRACTILITY, MECHANISMS, MUSCLE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background and objective: Clonidine has cardiac and systemic effects that can modify the potentially lethal cardiovascular effects of local anaesthetics. We evaluated the effects of clonidine pre-treatment on cardiotoxicity induced by an infusion of bupivacaine or ropivacaine and the success rate of resuscitation in anaesthetized rats.