Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.21, sa.3, ss.205-209, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 3
- Basım Tarihi: 2004
- Doi Numarası: 10.1017/s0265021504003072
- Dergi Adı: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.205-209
- Anahtar Kelimeler: local anaesthetics, bupivacaine, ropivacaine, cardiovascular agents, clonidine, drug toxicity, SELECTIVE ALPHA(2)-ADRENERGIC AGONIST, LOCAL-ANESTHETICS, CARDIAC RESUSCITATION, REGIONAL ANESTHESIA, CYTOSOLIC CA-2+, CONTRACTILITY, MECHANISMS, MUSCLE
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Background and objective: Clonidine has cardiac and systemic effects that can modify the potentially lethal cardiovascular effects of local anaesthetics. We evaluated the effects of clonidine pre-treatment on cardiotoxicity induced by an infusion of bupivacaine or ropivacaine and the success rate of resuscitation in anaesthetized rats.