Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats

Gulec S., Aydin Y., UZUNER K., Yelken B., Senturk Y.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, vol.21, no.3, pp.205-209, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1017/s0265021504003072
  • Journal Name: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.205-209
  • Keywords: local anaesthetics, bupivacaine, ropivacaine, cardiovascular agents, clonidine, drug toxicity, SELECTIVE ALPHA(2)-ADRENERGIC AGONIST, LOCAL-ANESTHETICS, CARDIAC RESUSCITATION, REGIONAL ANESTHESIA, CYTOSOLIC CA-2+, CONTRACTILITY, MECHANISMS, MUSCLE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background and objective: Clonidine has cardiac and systemic effects that can modify the potentially lethal cardiovascular effects of local anaesthetics. We evaluated the effects of clonidine pre-treatment on cardiotoxicity induced by an infusion of bupivacaine or ropivacaine and the success rate of resuscitation in anaesthetized rats.