Olopatadine hydrochloride loaded Kollidon (R) SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro-in vivo evaluation

GÜVEN, UMAY; YENİLMEZ, EVRİM

doi:10.1016/j.jddst.2019.03.016

Olopatadine hydrochloride loaded Kollidon (R) SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro-in vivo evaluation

Atıf İçin Kopyala

GÜVEN U. M., YENİLMEZ E.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.51, ss.506-512, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 51
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.jddst.2019.03.016
Dergi Adı: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.506-512
Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Introduction: Allergic eye diseases includes a spectrum of diseases, with each state being characterized by a complicated immunopathology. In the present study, polymeric Kollidon (R) SR nanoparticles loaded with olopatadine hydrochloride (OLO) were formulated as a suspension for ocular drug delivery. The formulations were developed to treat ocular allergic disease and characterized by their improved duration of corneal retention.