Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

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Alyu F., DİKMEN M.

ACTA NEUROPSYCHIATRICA, cilt.29, sa.1, ss.1-16, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 29 Konu: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1017/neu.2016.47
  • Sayfa Sayıları: ss.1-16


Objective Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined by disturbances of receptors in central nervous system. Besides, neurotransmitter distributions or other metabolic problems are supposed to involve in epileptogenesis. Lack of adequate data about pharmacological agents that have antiepileptogenic effects point to need of research on this field. Thus, in this review, inflammatory aspects of epileptogenesis has been focussed via considering several concepts like role of immune system, blood-brain barrier and antibody involvement in epileptogenesis.